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Table 3 Clinic pathological characteristics of HPV-positive and HPV-negative patients with ESCC

From: Heterozygote of TAP1 Codon637 decreases susceptibility to HPV infection but increases susceptibility to esophageal cancer among the Kazakh populations

Characteristics

Number

HPV+ Patients n = 204

HPV− Patients n = 112

χ 2

P value

n (%)

n (%)

Age (years), mean ± SD

316

53.01 ± 8.202

52.67 ± 10.141

 

0.746a

Age (years)

   

0.301

0,584

 <55

173

114 (65.9)

59 (34.1)

  

 ≥55

113

90 (62.9)

53 (37.1)

  

Gender

   

2.692

0,101

 Male

187

127 (67.9)

60 (32.1)

  

 Female

129

76 (58.9)

53 (41.1)

  

Smoking

   

0.081

0.775

 Yes

82

54 (65.9)

28 (34.1)

  

 No

234

150 (64.1)

84 (35.9)

  

Drinking

   

2.149

0.143

 Yes

65

47 (72.3)

18 (27.7)

  

 No

251

157 (62.5)

94 (37.5)

  

Location of the tumor

   

1.311

0.519

The upper thoracic portion

19

10 (52.6)

9 (47.4)

  

The mid-thoracic portion

170

112 (65.9)

58 (34.1)

  

The lower thoracic portion

127

82 (64.6)

45 (35.4)

  

Histologic grade

   

0.331

0.848

Well-differentiated (G1)

106

67 (63.2)

39 (36.8)

  

Moderately differentiated (G2)

162

107 (66.0)

55 (34.0)

  

Poorly differentiated (G3)

48

30 (62.5)

18 (37.5)

  

Depth of invasion

   

0320

0.572

T1/T2

188

119 (63.3)

69 (36.7)

  

T3/T4

128

85 (66.4)

43 (33.6)

  

Lymph node metastasis

   

1.127

0.288

No

193

129 (66.8)

64 (33.2)

  

Yes

123

75 (61.0)

48 (39.0)

  

Clinical stage

   

1.847

0.174

stage I/II

231

144 (62.3)

87 (37.7)

  

stage III/IV

85

60 (70.6)

25 (29.4)

  
  1. aStudent’s test