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Table 6 Stratification analysis to evaluate the association of HPV positive patients with TAP1 polymorphisms in Kazakh ESCC by tumor depth

From: Heterozygote of TAP1 Codon637 decreases susceptibility to HPV infection but increases susceptibility to esophageal cancer among the Kazakh populations

Parameters

TAP1 D637G (HPV+/HPV- patients)

OR (95 % CI)

TAP1 I333V (HPV+/HPV- patients)

OR (95 % CI)

AAa

AG/GG

AAa

AG/GG

Tumor depth

      

T1/T2

21/16

13/35

0.283 (0.114–0.703)**

23/27

11/24

0.538 (0.218–1.330)

T3/T4

27/9

14/15

0.311 (0.109–0.888)*

21/11

20/13

0.806 (0.294–2.212)

T1-T4

48/25

48/25

0.281 (0.144–0.551)***

44/38

31/37

0.724 (0.380–1.380)

  1. “*”represents P < 0.05, “**”indicates P < 0.01, “***”depicts P < 0.001
  2. aReference group. We consider the common homozygotes of TAP1 as ORs of 1.00 for the reference genotype