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Fig. 6 | Journal of Experimental & Clinical Cancer Research

Fig. 6

From: Notch signaling plays a crucial role in cancer stem-like cells maintaining stemness and mediating chemotaxis in renal cell carcinoma

Fig. 6

The effects of overexpression of notch 1 on chemotaxis of RCC CSCs induced by SDF-1. (a and b) Increased SDF-1 and CXCR4 induced by overexpression of notch1 in RCC CSCs. CXCR4 inhibitor AMD3100 decreased invasion (c and d) and migration (e and f) of RCC CSCs overexpressed by notch1. (g and h) Addition of SDF-1α and AMD3100 affected the cell viability of RCC CSCs overexpressed by notch1. (i and k) Addition of SDF-1α in the lower well in transwell assay, AMD3100 reduced overexpression of notch1-mediated chemotaxis in RCC CSCs. (j and l) Suppression of notch 1 induced by its inhibitor decreased CXCR4 in RCC CSCs. * P < 0.05 VS. indicated group; ** P < 0.01 VS. indicated group;*** P < 0.001 VS. indicated group

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