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Fig. 6 | Journal of Experimental & Clinical Cancer Research

Fig. 6

From: RETRACTED ARTICLE: Curcumin synergizes with 5-fluorouracil by impairing AMPK/ULK1-dependent autophagy, AKT activity and enhancing apoptosis in colon cancer cells with tumor growth inhibition in xenograft mice

Fig. 6

Analysis of anti-tumor effect of combination treatment of 5-Fu (30 mg/kg) and curcumin (40 mg/kg) and AMPK/ULK1-related autophagy in subcutaneous xenograft mice. a. Photographs of nude mice bearing HCT116-deliveried tumors after 25-day treatment. The tumor volume was measured using Vernier calipers and calculated as described in Materials and Methods. b. Western blots analysis of beclin-1, p62, LC3II/LC3I, P-AMPK and P-ULK1 expression levels in tumorous tissue of the mice. c. The change of food intake of the xenograft mice during the 25-day treatment. *, p < 0.05, and **, p < 0.01

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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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