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Fig. 5 | Journal of Experimental & Clinical Cancer Research

Fig. 5

From: Integrins as therapeutic targets in the organ-specific metastasis of human malignant melanoma

Fig. 5

Integrins responsible for the brain metastasis of melanoma and the inhibitors. Integrin αv, including αvβ3 and αvβ5, promotes the cell migration rate and the adherence of circulating melanoma cells to the brain vasculature, consequently increasing the occurrence of brain metastasis. Abergrin and MK-0429 selectively inhibit integrin αvβ3 by binding to the β3 subunit, whereas intetumumab and cilengitide inhibit both integrins by binding the αv subunit

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