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Fig. 6 | Journal of Experimental & Clinical Cancer Research

Fig. 6

From: (Arg)9-SH2 superbinder: a novel promising anticancer therapy to melanoma by blocking phosphotyrosine signaling

Fig. 6

(Arg)9-GST SH2 TrM induced apoptotic death of B16F10 cells. a Flow cytometry measurement of cell apoptosis induced by (Arg)9-GST SH2 TrM at different time of incubation (n = 3, *P < 0.05). Q1: necrotic cells, Q2: late apoptotic cells; Q3: early phase apoptotic cells; Q4: normal cells. b (Arg)9-GST SH2 TrM treatment regulated the expression of Bax and Bcl-2. c Level of pSTAT3 and STAT3 was examined by Western Blot. GAPDH was used as a loading control. All cells were incubated with (Arg)9-GST SH2 TrM at 1 μM for 2 h before collected. Data shown are representative of three independent experiments

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