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Table 1 Meta-analysis of upregulated protein in acid exosomes through PrognoScan

From: Acidic microenvironment plays a key role in human melanoma progression through a sustained exosome mediated transfer of clinically relevant metastatic molecules

Gene

GenBank ID*

Probe name

Mentel-Cox p-value**

HRAS

3265

212983_at

0.010599

IQGAP1

8826

213446_s_at

NS

ACTN1

87

200601_at

NS

ACTN4

81

208636_at

NS

CDC42

998

214230_at

NS

CFL1

1072

1555730_a_at

NS

CFL2

1073

233496_s_at

0.002532

FN1

2335

210495_x_at

NS

NRAS

4893

202647_s_at

0.002301

GSN

2934

202647_s_at

0.044629

VCL

7414

200930_s_at

NS

CD44

960

229221_at

NS

TIMP3

7078

201147_s_at

0.029350

THBS1

7057

201110_s_at

NS

TLN1

7094

203254_s_at

NS

CTNND1

1500

1557944_s_at

NS

ICAM1

3383

215485_s_at

NS

DNAJA2

10,294

209157_at

NS

GANAB

23,193

214626_s_at

0.003695

HSP90AA1

3320

211968_s_at

NS

HSP90B1

7184

216449_x_at

0.040481

HSP90AB1

3326

200064_at

0.029072

HSPA1L

3305

233694_at

0.048446

HSPA5

3309

230031_at

0.026684

HYOU1

10,525

200825_s_at

0.037596

VCP

7415

214990_at

NS

  1. *publicly accessible at https://0-www-ncbi-nlm-nih-gov.brum.beds.ac.uk/gene
  2. **Numbers depict Mentel-Cox p values for gene expression with significant difference in patient’s overall survival. Only values with p < 0.05 are indicated. NS, patient’s overall survival not significant (p > =0.05) for the indicated high or low gene expression. The analysis was performed by interrogating PrognoScan database for gene expression in cancer tissue samples versus overall survival rates of patients with metastatic melanoma. All the listed genes refer to proteins involved in metastatic processes found upregulated in acid exosomes (Additional file 12). The analysis has been performed by using the dataset GSE19234, publicly accessible at GEO database [34]