Fig. 4From: TNF-alpha and metalloproteases as key players in melanoma cells aggressivenessa Weak, not significant, MMP2 mRNA up-regulation in A375 compared to SK-MEL-28. b Highly significant (§§p < 0.00001; §p < 0.0001) down-regulation of Tissue Inhibitor of Metalloproteinases (TIMP) c The MMP2 activity evaluated by a gelatin zymography confirming the higher aggressiveness of A375 cells compared to SK-MEL-28Back to article page