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Table 1 Biodistribution of 131I-5-IPN in B16F10 melanoma bearing C57BL/6 mice and A375 melanoma bearing BALB/C-nu/nu mice at different time pi. (% ID/g, mean ± SD)

From: Targeted radiotherapy of pigmented melanoma with 131I-5-IPN

 

B16F10 melanoma (n = 5)

Blocked B16F10 melanoma (n = 5)

A375 melanoma (n = 5)

1 h

6 h

24 h

48 h

72 h

1 h

1 h

Organ

 Blood

4.05 ± 1.06

1.44 ± 0.35

0.05 ± 0.01

0.04 ± 0.02

0.03 ± 0.03

0.07 ± 0.02

0.09 ± 0.02

 Brain

0.94 ± 0.21

0.11 ± 0.01

0.02 ± 0.02

0.01 ± 0.01

0.01 ± 0.00

0.06 ± 0.01

0.04 ± 0.02

 Heart

2.20 ± 0.38

0.47 ± 0.11

0.24 ± 0.16

0.06 ± 0.05

0.04 ± 0.04

0.11 ± 0.03

0.15 ± 0.05

 Lungs

5.82 ± 4.34

1.35 ± 0.18

0.36 ± 0.17

0.27 ± 0.09

0.08 ± 0.10

0.16 ± 0.03

0.19 ± 0.04

 Liver

19.81 ± 0.38

4.12 ± 0.30

1.53 ± 0.25

0.82 ± 0.28

0.46 ± 0.48

1.35 ± 0.20

1.52 ± 0.25

 Spleen

4.06 ± 1.50

0.87 ± 0.09

0.39 ± 0.26

0.33 ± 0.30

0.05 ± 0.06

0.34 ± 0.15

0.11 ± 0.02

 Kidney

5.87 ± 1.74

1.14 ± 0.15

0.18 ± 0.07

0.11 ± 0.04

0.05 ± 0.03

0.61 ± 0.53

0.17 ± 0.01

 Stomach

5.22 ± 1.55

2.24 ± 1.43

0.08 ± 0.02

0.11 ± 0.10

0.05 ± 0.03

0.17 ± 0.09

0.51 ± 0.28

 Large intestine

3.43 ± 0.52

0.72 ± 0.36

0.11 ± 0.06

0.06 ± 0.06

0.05 ± 0.06

0.29 ± 0.07

0.17 ± 0.04

 Small intestine

3.56 ± 0.40

0.79 ± 0.47

0.05 ± 0.01

0.05 ± 0.03

0.02 ± 0.01

0.38 ± 0.18

0.18 ± 0.03

 Muscle

1.18 ± 0.33

0.28 ± 0.03

0.02 ± 0.02

0.01 ± 0.00

0.02 ± 0.01

0.07 ± 0.02

0.17 ± 0.04

 Bone

3.24 ± 1.50

0.65 ± 0.08

0.12 ± 0.03

0.56 ± 0.89

0.04 ± 0.07

0.16 ± 0.01

0.17 ± 0.05

 Tumor

16.37 ± 3.32

14.33 ± 3.30

7.41 ± 2.21

4.26 ± 1.36

3.31 ± 1.45

2.67 ± 1.16

0.15 ± 0.12

 Thyroid

6.51 ± 2.13

1.36 ± 0.17

0.11 ± 0.04

0.08 ± 0.05

0.04 ± 0.06

0.29 ± 0.08

0.25 ± 0.02

 Eyes

22.45 ± 4.74

15.02 ± 2.12

11.27 ± 0.90

9.77 ± 1.02

7.17 ± 0.96

4.66 ± 1.10

0.30 ± 0.02

Uptake ratio

 Tumor-to-blood

4.16 ± 0.74

10.04 ± 0.75

151.3 ± 64.35

132.9 ± 124.9

188.1 ± 110.9

50.56 ± 40.23

1.49 ± 1.02

 Tumor-to-liver

0.85 ± 0.18

3.47 ± 0.70

4.91 ± 1.65

5.45 ± 2.16

10.49 ± 5.01

1.96 ± 0.73

0.10 ± 0.07

 Tumor-to-muscle

14.53 ± 3.33

51.72 ± 13.58

248.4 ± 143.7

121.5 ± 66.76

123.4 ± 37.89

40.08 ± 16.20

0.82 ± 0.29