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Fig. 7 | Journal of Experimental & Clinical Cancer Research

Fig. 7

From: Kinase inhibitor library screening identifies synergistic drug combinations effective in sensitive and resistant melanoma cells

Fig. 7

Pathways affected by the combined selected kinase inhibitors in BRAF mutant melanoma cells. Scheme summarizing the effects of cell cycle-influencing proteins targeted by the identified kinase inhibitors (black boxes). The pathway on the right (grey background) represents mitogenic factor-induced or mutated BRAF-induced entry into the cell cycle, while the left box (blue background) depicts players involved in progression through the different checkpoints and phases of the cell cycle. cdc25: cell division cycle 25

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