Fig. 7

Overexpression of TRIM44 and TLR4 is an indicator for poor prognosis in melanoma patients. a and b, Representative bands of TRIM44 and TLR4 protein levels in 20 melanoma tissues are shown. Analyses of the correlation between TRIM44 and TLR4 was performed using the Spearman correlation coefficient. c and d, TRIM44 and TLR4 mRNA levels in 20 melanoma tissues. Analysis of the correlation between TRIM44 and TLR4 was performed using the Spearman correlation coefficient. There was a positive relationship between TRIM44 and TLR4 at the protein level, but not the mRNA level. e, Representative images of TMA stained with H&E, immunohistochemistry for TRIM44 and TLR4. f, Correlation analysis of the relative IOD values of TRIM44 and TLR4 using the Spearman correlation coefficient. TRIM44 positively correlated with TLR4 at the protein level. g, Kaplan-Meier analyses showing relationships between differential expression of TRIM44 and TLR4 and either overall survival or recurrence using the log-rank test. High levels of TRIM44 and TLR4 were associated with shortened overall survival and higher recurrence rates. ^* p < 0.05, ^***p < 0.001. T, tumor; P, peritumor