Table 4 Association of TAP1 gene polymorphisms with risk of Kazakh ESCC

TAP1 D637G

 AA^a

73 (48.7)

173 (61.1)

1.000 (reference)

 AG

70 (46.7)

102 (36.1)

0.019

1.626 (1.080–2.449)

 GG

7 (4.7)

8 (2.8)

0.246^b

2.074 (0.725–5.930)

Combined variant genotypes

 AG + GG

77 (51.3)

110 (38.9)

0.013

1.659 (1.112–2.474)

 A^a

216 (72.0)

448 (79.2)

1.000 (reference)

 G

84 (28.0)

118 (20.8)

0.018

1.477 (1.068–2.040)

TAP1 I333V

 AA^a

82 (54.7)

134 (47.3)

1.000 (reference)

 AG

62 (41.3)

130 (46.0)

0.232

0.780 (0.518–1.173)

 GG

6 (4.0)

19 (6.7)

0.170

0.516 (0.198–1.345)

Combined variant genotypes

 AG + GG

68 (45.3)

149 (52.7)

0.112

0.724 (0.486–1.079)

 A^a

226 (72.0)

398 (70.3)

1.000 (reference)

 G

74 (24.7)

168 (29.7)

0.118

0.776 (0.564–1.067)