Fig. 5

The combination of PRS and NSC synergistically prevents the proliferation of several AML cell lines. a) Effect of 48 h individual and combined treatments with PRS and NSC on HL-60 cells proliferation. b) Mean CI values for the drug combinations tested. Differences were tested between CI obtained values and 1. c) Percentage of viable HL-60 cells after 48 h of individual and combined treatments. d) Effect of 48 h treatment with the individual drugs and their combination on the proliferation rate of the specified cell lines. e) Mean CI values for the drug combinations tested in the different cell lines. Comparisons were made against the value 1. f) HL-60 colony numbers upon 48 h individual and combined treatment, drug removal, seeding and culture for 7 days. g) Percentage of apoptotic (Annexin V⁺) HL-60 cells after 48 treatment with the individual drugs and their combination