Table 1 Change of sensitivity of the HCT-8 cells to chemotherapeutic drugs after the treatment of 3 μM ivermectin
From: Ivermectin reverses the drug resistance in cancer cells through EGFR/ERK/Akt/NF-κB pathway
Test drugs | IC50 (μM) | Sensitivity ratios | ||||
|---|---|---|---|---|---|---|
S | R | [IC50 (- IVM)/IC50 (+ IVM)] | ||||
- IVM | + IVM | - IVM | + IVM | S | R | |
Vincristine | 0.081 ± 0.001 | 0.027 ± 0.001 | 1.015 ± 0.003 | 0.032 ± 0.001 | 2.96 | 31.15 |
Mitomycin C | 2.71 ± 0.32 | 1.34 ± 0.22 | 26.62 ± 0.51 | 4.81 ± 0.32 | 2.02 | 5.53 |
Adriamycin | 5.42 ± 0.34 | 0.42 ± 0.12 | 36.34 ± 0.93 | 0.74 ± 0.14 | 12.90 | 49.11 |