Fig. 7From: Tumor-derived exosomal ADAM17 promotes pre-metastatic niche formation by enhancing vascular permeability in colorectal cancerA schematic model showing the functions of exosomal ADAM17 in CRC hematogenous metastasis. The current study indicated the presence of intercellular communication between mesenchymal cancer cells and the vascular endothelium. EMT-CRC-derived exosomal ADAM17 disrupts expression of the adherent junction protein VE-cadherin, thus dysregulating the vascular barrier and facilitating the generation of CTCs and metastasisBack to article page